Whitehead Institute for Biomedical Research;Massachusetts Institute of Technology;The Broad Institute, Inc.
发明人:
Vincent Benjamin,Whitesell Luke,Lindquist Susan L.,Youngsaye Willmen,Buchwald Stephen L.,Langlois Jean-Baptiste,Pu Jun,Munoz Benito,Dandapani Sivaraman
申请号：
US201314435790
公开号：
US9944607(B2)
申请日:
2013.10.16
申请国别(地区):
美国
年份:
2018
代理人:
Wolf, Greenfield & Sacks, P.C.
摘要：
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrate, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive Compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoan, or inhibiting the growth of a fungus or protozoan. The fungus may be a Candida species, Sacchawmyces species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan mitochondrial phosphate carrier protein.
