A method and apparatus disinfecting a computer keyboard includes a metal ion treatment applied to the computer keyboard and other user input devices. A further measure taken is the installation of a shutoff mechanism in the link connecting the computer keyboard to the computer system to open the data connections between the keyboard and host system. Another measure is the periodic and reiterated wipedown of the keyboard and ancillary input devices with an antiseptic wipe. The shutoff mechanism is turned off before the wipedown procedure is carried out, to prevent any incidental keyboard entries made during the wipedown process from being transmitted to the host system.