The present invention provides a pharmaceutical preparation for treating a cardiovascular disease. Particularly, the present invention provides a formula of a neuregulin pharmaceutical preparation. The formula, which consists of neuregulin polypeptide, a buffer, a stabilizer, an excipient, a salt, and other components, can ensure the long-term stability of the neuregulin polypeptide, and can be used for treating a patient suffering from or at risk of developing heart failure.