PROBLEM TO BE SOLVED: To provide methods for treating disorders associated with metabotropic glutamate receptors (mGluRs) by simultaneously inhibiting at least two mGluRs belonging to at least two different groups.SOLUTION: There are provided methods for treating disorders associated with mGlu receptors 2, 3, and 5, such as nicotine addiction, cocaine addiction, and depression, the method including administering to a subject in need thereof an effective amount of at least one antagonist which modulates mGluR2, mGluR3, and mGluR5.【課題】少なくとも二つの異なるグループに属する代謝型グルタミン酸受容体（ｍＧｌｕＲ）の少なくとも二つを同時に阻害することによる、ｍＧｌｕＲに関連する疾患の処置法の提供。【解決手段】ｍＧｌｕＲ２、ｍＧｌｕＲ３、およびｍＧｌｕＲ５を調節する少なくとも一つのアンタゴニストの有効量を必要とする対象に投与することを含む、ｍＧｌｕ受容体２、３および５に関連する、ニコチン嗜癖、コカイン嗜癖、および鬱病等の疾患の処置法。【選択図】なし
