PROBLEM TO BE SOLVED: To provide a duloxetine-containing pharmaceutical composition that attains both an improvement of dissolution property at pH 6.8 and suppression of generation of an analogous substance.SOLUTION: According to the present invention, there is provided an oral pharmaceutical composition comprising a drug layer and an enteric layer. Here, the drug layer comprises duloxetine hydrochloride and a pharmaceutically acceptable additive. The enteric layer comprises carboxymethylethylcellulose as an enteric polymer and a pharmaceutically acceptable additive, and covers the drug layer.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】デュロキセチン含有医薬組成物において、pH6.8での溶出性の改善と類縁物質の生成の抑制とを両立させる。【解決手段】経口医薬組成物は、薬物層と腸溶層とを含む。薬物層は、デュロキセチン塩酸塩と薬学的に許容し得る添加剤とを含む。腸溶層は、腸溶性ポリマーとしてカルボキシメチルエチルセルロースと、薬学的に許容し得る添加剤とを含み、薬物層を覆う。【選択図】なし
