Efficient delivery of therapeutic molecules to cells of the inner ear

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专利权人:

发明人:

Zheng-Yi Chen

申请号：

US15523317

公开号：

US20170327557A1

申请日:

2015.10.29

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

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中国工程科技知识中心

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http://www.ckcest.cn/home/