VALENTINA MOLTENI,ADVAIT SURESH NAGLE,FRANTISEK SUPEK,VINCE YEH,AGNES BIGGART,CASEY JACOB NELSON MATHISON,FANG LIANG
申请号：
ARP140104775
公开号：
AR098844A1
申请日:
2014.12.19
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
This document provides pharmaceutical ingredients, including compounds and methods of using them, to treat, prevent, inhibit, improve or eliminate the pathology and / or symptoms of diseases caused by parasites, such as leishmaniasis, African trypanosomiasis and South American trypanosomiasis. 1. Claim 1: a formula compound (1),a. It is either a pharmaceutically acceptable salt or its stereoisomer, in which: A-ring is phenyl or pyridine； X is - C (o) - O-S (o) 8322 -；R1 was selected from nitrogen, tar c8321c831832424；C₁₋₆ alkoxy,amino, Cila alkylamino,di-alkylamino C₁₋₆,cycloalkyl C₃₋₆,C₄₋₆ heterocycloalkyl,C₄₋₈ heterocycloalkenyl,and heteroaryl C₅₋₉,There, alcoxyl c83217c833126；Lease c8332121；cycloalkyl C₃₋₆,C₄₋₆ heterocycloalkyl,C₄₋₈ heterocycloalkenyl,or C₅₋₉ heteroaryl of R¹ is substituted or unsubstituted by 1 to 2 substituents independently selected from halogen, cyano, C₁₋₄-alkyl,haloalkyl C₁₋₄,C₁₋₄ alkoxy,Amino, rental c83217c83318324,Di-di-di lease c8332138.31832424；e. Mercury and tar c83218331；R³ is selected from hydrogen, halogen； cyano； C₁₋₄-alkyl；a. Halogenated tar c831832421；N is 0, 1, or 2； r8311 is selected from c832131 hydrogen or hydrocarbon；L³ is a bond, phenylene or heteroarylene C₅₋₆；R830404 was selected from hydrogen, hydroxyl, halogen, nitrogen-n = CHN (ch832323) 832222；1. Lease of c83218331 and 83242431；heterocycloalkyl C₄₋₆alkyl C₁₋₄,C₁₋₄ alkoxy,-7491； 74955；-8309； C (o) r8310；-8309； s (o) 8322； r831222；-Yes (ch832323) 8323；cycloalkyl C₃₋₆,cycloalkenyl C₅₋₆,C₄₋₆ heterocycloalkyl,C₅₋₈ heterocycloalkenyl,aryl C₆₋₁₀,e. Heterosexual c83325583；wherein the C₁₋₄-alkyl or C₁₋₄-alkoxy of the R sustitu is substituted or unsubstituted by 1-2 substituents independently selected from C₁₋₄-alkoxy,amino, phenyl and heteroaryl C₅₋₆；wherein the C₅₋₆ phenyl or heteroaryl substituent is unsubstituted or further substituted by halogen or C₁₋₄ alkyl；cycloalkyl C₃₋₆,cycloalkenyl C₅₋₆,C₄₋₆ heterocycloalkyl,C₅₋₈ heterocycloalkenyl,aryl C₆₋₁₀,and C₅₋₆ heteroaryl of
