Dang Phuong Grace,Dang Phuong Grace,Lawrence Brian D.,Lawrence Brian D.,Balwani Gul,Balwani Gul,DAddio Alexander D.,DAddio Alexander D.
申请号：
SI200532126
公开号：
SI2377557T1
申请日:
2005.11.22
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or intraocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, or allergic conjunctivitis. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.
