Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.本發明提供對受體蛋白質酪胺酸激酶c-kit及/或c-fms具有活性之化合物。本發明亦提供可用於治療由c-kit介導之疾病或病症及/或由c-fms介導之疾病或病症的組合物及其使用方法。