Eric L. Stangeland;Mathai Mammen;Sarah Dunham;Adam D. Hughes;Craig Husfeld
发明人:
Mathai Mammen,Sarah Dunham,Adam D. Hughes,Craig Husfeld,Eric L. Stangeland
申请号:
US13545523
公开号:
US08618131B2
申请日:
2012.07.10
申请国别(地区):
US
年份:
2013
代理人:
摘要:
This invention provides biphenyl derivatives of formula I:wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthmas.