Refers to an isolated monoclonal antibody that specifically binds to human PCSK9.Where the Antibody comprises a variable region of heavy chain comprising at least one amino acid in a specific position selected from the group consisting of T28, S30 S31, Y32, S54 S55,,S56, y57, I58, S59 y60, N74, A75, R98, y100, F102, w103, S104, A105, y106 y107 d108,,,A109 D111 and SEQ ID no: 67 and a variable region of light chain comprising at least one amino acid in a specific group of L48, S51 and 93 and S98 of SEQ ID no: 12.It also relates to a Pharmaceutical composition comprising Said Antibody.These Antibodies are useful in Methods for treating hypercholesterolemia and other disorders, and to detect the quantity of PCSK9 in a SampleSe refiere a un anticuerpo monoclonal aislado que se une especificamente a PCSK9 humano, donde el anticuerpo comprende una region variable de cadena pesada que comprende al menos un aminoacido en la posicion especifica seleccionada del grupo que consiste en T28, S30, S31, Y32, S54, S55, S56, Y57, I58, S59, Y60, N74, A75, R98, Y100, F102, W103, S104, A105, Y106, Y107, D108, A109 y D111 de SEQ ID NO: 67 y una region variable de cadena liviana que comprende al menos un aminoacido en el grupo especifico que consiste en L48, S51, Y93 y S98 de SEQ ID NO: 12. Tambien se refiere a una composicion farmaceutica que comprende dicho anticuerpo. Dichos anticuerpos son utiles en metodos para tratar la hipercolesterolemia y otros trastornos, y para detectar la cantidad de PCSK9 en una muestra
