POSY, SHOSHANA L.,SIVAPRAKASAM, PRASANNA,GANGWAR, SANJEEV,POUDEL, YAM B.
申请号：
ARP180102338
公开号：
AR112687A1
申请日:
2018.08.15
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
1. Claim 1: a compound (1) with formula structure characteristics,(2) Or (3),where R¹ is (C₁₋₅ alkyl) O, (C₁₋₂ alkyl) O (CH₂) ₂₋₃O, (C₁₋₅ alkyl) C (= O) O, (C₁₋₅ alkyl) NH, (C₁₋ ₂ alkyl) O (CH₂) ₂₋₃NH or (C₁₋₅ alkyl) C (= O) NH； R² and R³ are, independently of each case, H, C₁₋₃ alkyl, halo, O (C₁₋₃ alkyl),I am meIn R3, it can be replaced by (ch.8322) 739； r83088；At x level, the index is 1, 2, 3 or 4； r8308es is h, halo, oh, CN, nh8322；NH (C₁₋₅ alkyl),N (C₁₋₅ alkyl) ₂,NH (C cicloalquilo)NH (C bicicloalquilo)NH (C espirocicloalquilo)N (C cicloalquilo)NH (CH) (arilo)N ((CH) (arilo))A periodic ammonia part has a formula structure (4),a 6-membered aromatic or heteroaromatic portion or a 5-membered heteroaromatic portion； wherein an alkyl, cycloalkyl, bicycloalkyl, spirocycloalkyl, cyclic, aromatic or 6-membered heteroaromatic or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C₁₋₃ alkyl),O (C alquilo)This is my life.SO₂ (C₁₋₃ alkyl),C (3DO) (Et)NH.8322；Me, IN (Me)NH (Et)N (Et) ₂ and N (C₁₋₃ alkyl) ₂；and a cycloalkyl, bicycloalkyl, spirocycloalkyl or cyclic amine moiety may have a CH₂ group replaced by O, S, NH, N (C₁₋₃ alkyl) or N (Boc)；R8309es, regardless of case, O, s or n8310es；R⁶ is H or C₁₋₃ alkyl； X¹ is, independently of each case, CR² or N； X² is, independently of each case, CR³ or N； and X³ is O, S, NH, N (C₁₋₃ alkyl),C 3DO o N (C 3DO) (C alquilo)Reivindicación 1: Un compuesto caracterizado porque tiene una estructura de acuerdo con la fórmula (1), (2) ó (3), en donde R¹ es (C₁₋₅ alquil)O, (C₁₋₂ alquil)O(CH₂)₂₋₃O, (C₁₋₅ alquil)C(=O)O, (C₁₋₅ alquil)NH, (C₁₋₂ alquil)O(CH₂)₂₋₃NH o (C₁₋₅ alquil)C(=O)NH； R² y R³ son, independientemente de cada caso, H, C₁₋₃ alquilo, halo, O(C₁₋₃ alquilo), CN o NO₂, en donde un R³ se puede reemplazar por (CH₂)ˣR⁴, en donde el subíndice x es 1, 2, 3 ó 4； R⁴ es H, halo, OH, CN, NH₂, NH(C₁₋₅ alquilo), N(C₁₋₅ alquilo)₂, NH(C₃₋₆ cicloalquilo), NH(C₄₋₈ bicicloalquilo), NH
