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VECTORS ENCODING THE VALVE FACTOR OF RADIES OBTAINED FROM WANDS
专利权人:
ВЕЛЛСТАТ ОФТЭЛМИКС КОРПОРЭЙШН (US)
发明人:
ЛУО Тианси (US)
申请号:
RU2014121256/15
公开号:
RU2014121256A
申请日:
2012.10.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A nucleic acid containing a nucleotide sequence that encodes a coding sequence for an RdCVF protein, where the sequence encoding RdCVF contains a transcoded nucleotide sequence. The nucleic acid of claim 1, wherein the RdCVF protein is an RdCVF1.3 protein. The nucleic acid of claim 1, wherein the RdCVF protein is an RdCVF2.4 protein. The nucleic acid of claim 1, wherein the RdCVF protein is a short version of the RdCVF protein. The nucleic acid of claim 1, wherein the RdCVF protein is a long version of the RdCVF protein. The nucleic acid of claim 1, wherein the RdCVF protein is a human RdCVF protein. The nucleic acid according to claim 1, wherein the initial methionine codon is missing in the encoded nucleotide sequence. The nucleic acid of claim 1, wherein the coding sequence for the RdCVF protein comprises nucleotides 106-741 from SEQ ID NO: 1, nucleotides 106-429 from SEQ ID NO: 1, nucleotides 106-432 from SEQ ID NO: 3, or nucleotides 106- 744 of SEQ ID NO: 3.9. The nucleic acid of claim 1, further comprising a second coding region for the N-terminal signal sequence operably linked to the coding sequence for the RdCVF protein. The nucleic acid of claim 9, wherein the signal sequence is selected from the group consisting of an Igk signal sequence, human growth hormone (HGH), neurotrophic factor derived from the brain (BDNF), insulin growth factor 1 (IGF-1), and β- glucuronidase (GUSB) .11. The nucleic acid of claim 9, wherein the signal sequence comprises nucleotides 1-105 of SEQ ID NO: 1.12. The nucleic acid of claim 9, wherein the signal sequence encodes an amino acid sequence containing1. Нуклеиновая кислота, содержащая последовательность нуклеотидов, которая кодирует кодирующую последовательность для белка RdCVF, где последовательность, кодирующая RdCVF, содержит перекодированную последовательность нуклеотидов.2. Нуклеиновая кислота по п. 1, где белок RdCVF представляет собой белок RdCVF1.3. Нуклеиновая кислота по п. 1, где белок RdCVF представляет собой бе
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