An allisartan isoproxil solid dispersion with high loading and high stability is provided, which includes allisartan isoproxil and a pharmaceutically acceptable carrier material. The carrier material contains a solubilizing carrier. A mass ratio between the allisartan isoproxil and the solubilizing carrier in the allisartan isoproxil solid dispersion ranges from 1 : 0.2 to 0.45. An allisartan isoproxil pharmaceutical composition having the allisartan isoproxil solid dispersion is further provided, which has advantages of high stability, good solubility, and high medication compliance, etc.本發明提供了一種負載量高、穩定性高的阿利沙坦酯固體分散體，其包括阿利沙坦酯和藥學上可接受的載體材料，該載體材料含有增溶載體，其中該阿利沙坦酯固體分散體中，該阿利沙坦酯與蓋增溶載體的質量比為1：0.2~0.45。本發明於此基礎上進一步提供了一種含有該固體分散體的阿利沙坦酯藥物組合物。該阿利沙坦酯藥物組合物具有穩定性高，溶出性能好，藥物遵從性高等優點。
