Disclosed is a multi-layer oral film comprising at least two non-adhesive layers each containing at least one hydrophobic polymer, and at least one water-soluble adhesive layer containing at least one water-soluble polymer and at least one plasticizer, wherein at least one of the at least two non-adhesive layers and/or the at least one water-soluble adhesive layer contains a pharmaceutically active substance and the at least two non-adhesive layers and the at least one water-soluble adhesive layer alternate in such a way that the at least one water-soluble adhesive layer is covered on both sides by at least one non-adhesive layer.
