University Of Southern California;Nationwide Children's Hospital, Inc.
发明人:
GOODMAN, Steven D.,BAKALETZ, Lauren O.
申请号：
ES11712739
公开号：
ES2754240T3
申请日:
2011.03.28
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
An interfering agent that inhibits, competes, or evaluates the binding of a DNABII protein or polypeptide to microbial DNA for use in a method of inhibiting, preventing, or treating a biofilm that produces a biofilm in a subject by inhibiting, preventing, or decomposing from the microbial biofilm, and wherein the interfering agent is one or more of: (a) an isolated or recombinant host integration factor (IHF) polypeptide； (b) a histone-like protein isolated or recombinant from an E. coli strain U93 (HU) polypeptide； (c) an isolated or recombinant polypeptide of SEQ ID NOS: 1 to 35, 37 to 340； (d) an isolated or recombinant polypeptide comprising the C-terminal region containing at least 10 C-terminal amino acids of a polypeptide of SEQ ID NOS: 6 to 11, 28, 29, 42 to 100； (e) a polypeptide or polynucleotide that competes with a host integration factor in binding to a microbial DNA； (f) an isolated or recombinant DNABII polypeptide； (g) an HU polypeptide； (h) a four-way junction polynucleotide that resembles a Holliday junction or a 3-way junction polynucleotide that resembles a replication hairpin； (i) an isolated or recombinant polynucleotide of SEQ ID NO: 36； (j) an antibody or antigen-binding fragment that specifically recognizes or binds any one of (a) to (g)； (k) an isolated or recombinant high mobility box group (HMGB) 1 protein； or (l) an isolated or recombinant protein or polypeptide that has at least 80% sequence identity with a protein or polypeptide of any one of (a) to (d), (f), (g) or (k) , or an antibody or antigen-binding fragment having at least 80% sequence identity with an antibody or antigen-binding fragment of (j).Un agente interferente que inhibe, compite o valora la unión de una proteína o polipéptido DNABII a un ADN microbiano para su uso en un método de inhibición, prevención o tratamiento de una infección microbiana que produce una biopelícula en un sujeto mediante inhibición, prevención o descomposición de la biopelícula microbiana, y en el
