稠和雙環C5aR拮抗劑之前藥农业专利-农业学术服务平台

发明人:: FAN, PINGCHEN,樊　平臣,LUI, REBECCA M.,雷　敏瑜,SINGH, RAJINDER,斯颖　罗瑾德,斯穎　羅瑾德,MALI, VENKAT REDDY,马利　帆克　罗迪,馬利　帆克　羅迪,ZENG, YIBIN,曾一斌,ZHANG, PENGLIE,张　朋烈,張　朋烈

摘要：: The present disclosure provides, inter alia, Compounds of Formulae IA, IB, IC, IIA, IIB and IIC or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.本發明特別提供式IA、IB、IC、IIA、IIB及IIC化合物：或其醫藥上可接受之鹽，其等係C5a受體之調節劑。本發明亦提供醫藥組合物及使用方法，包括涉及C5a之病理活化之疾病或病症之治療及非醫藥應用。