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PROCESS FOR THE PREPARATION OF TYROSINE KINASE INHIBITOR
专利权人:
发明人:
RAO DHARMARAJ RAMACHANDRA,MALHOTRA GEENA,PATHI SRINIVAS LAXMINARAYAN,CHINIMILLI VENUGOPALARAO,BORUSU VYAGHRI GANGARAJU
申请号:
IN201621003389
公开号:
IN201621003389A
申请日:
2016.01.30
申请国别(地区):
IN
年份:
2017
代理人:
摘要:
The invention relates to a novel process for the preparation of indazole, compound of formula (I) and to intermediates thereof, the process comprising . (a) reacting indazole compound (V) with dithio-2,2-bis(N-methylbenzamide compound (IV) in the presence of copper catalyst and a suitable ligand to form compound (II) Formula II wherein R1 is an activated substituent group, a substituted or unsubstituted aryl or heteroaryl, or a group of the formula CH=CHR3 or CH=NR3, where R3 is a substituted or unsubstituted alkyl, alkenyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl and R2 is H, or protecting group wherein X is an activated substituent group and (b) converting compound (II) into compound (I).
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