The present invention features, in part, methods of treating or preventing vascular diseases of the retina in a subject, methods of treating or preventing angiogenesis in a subject and methods of treating or preventing neovascularization in a subject comprising administering to a subject a therapeutically effective amount of an inhibitor of cytochrome P450 2C8 (CYP2C8) activity or expression, or a promoter of sEH activity or expression.