The General Hospital Corporation;Childrens Medical Center Corporation;Children's Medical Center Corporation
发明人:
Zon, Leonard I.,North, Trista E.,Goessling, Wolfram
申请号：
AU2017202149
公开号：
AU2017202149B2
申请日:
2017.03.31
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2017202149B220181206.pdf#####ABSTRACT The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HSC modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HSC modulators may be used in vitro, in vivo, or ex vivo.
