Compositions, systems, methods and techniques are disclosed for the diagnosis and treatment of ischemic conditions, non-healing wounds or bone fractures, articular joints, graft materials, tissue implants and other tissue pathologies. Patients with ischemic disease can be categorized into various subsets that are deemed to have potential to respond to therapy. In particular, therapies are disclosed which involve stimulation of angiogenesis and/or neovascularization so as to increase perfusion of various anatomical features.
