Jianming Bao;Fengqi Zhang;Sandra L. Knowles;Michael Man-Chu Lo;Robert D. Mazzola, Jr.;Chunsing Li;Andrew W. Stamford;Xiaolei Gao;Debra L. Ondeyka
发明人:
Jianming Bao,Xiaolei Gao,Sandra L. Knowles,Chunsing Li,Michael Man-Chu Lo,Robert D. Mazzola, Jr.,Debra L. Ondeyka,Andrew W. Stamford,Fengqi Zhang
申请号：
US15386009
公开号：
US10329289B2
申请日:
2016.12.21
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is directed to 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-5-one compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
