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NOVEL DERIVATIVES OF A 3,4-DIHYDROISOQUINOLINE-3-CARBOXYLIC ACID HAVING ANTI-CANCER PROPERTIES, A METHOD FOR THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES, AND THEIR USE
专利权人:
NARODOWY INSTYTUT ZDROWIA PUBLICZNEGO PANSTWOWY ZAKL HIGIENY
发明人:
申请号:
EP14766002.1
公开号:
EP3027591B1
申请日:
2014.07.29
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
The object of the invention is 3,4-dihydroisoquinoline derivative of structure represented by formula I, wherein R1is selected from the group consisting of H, COOEt, COOH, COOBn R2 is selected from the group consisting of H, COOEt, COOH, COOBn R3is selected from the group consisting of OH, OBn R4is selected from the group consisting of OH, H, OBn Rsis selected from the group consisting of OH, OBn and isomers, salts, hydrates and solvates thereof, as well as the method of preparation thereof pharmaceutical composition comprising the above mentioned derivative and use thereof.
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