DAE HAE SONG;SE CHANG KWON;SUNG MIN BAE;YOUNG JIN PARK;JAE HEE SHIN;HANMI SCIENCE CO. LTD.;DAE SEONG IM
发明人:
DAE HAE SONG,SE CHANG KWON,SUNG MIN BAE,YOUNG JIN PARK,JAE HEE SHIN,DAE SEONG IM
申请号：
IL22231912
公开号：
IL222319A
申请日:
2012.10.09
申请国别(地区):
IL
年份:
2019
代理人:
摘要：
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.
