Disclosed herein are quinolone compound represented by General Formula (1), wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful as a prophylactic and/or therapeutic agent for neurodegenerative diseases induced by neurological dysfunction or diseases induced by deterioration of mitochondrial function, such as Parkinsons disease, Parkinsons syndrome, juvenile parkinsonism, striatonigral degeneration, progressive supranuclear palsy, pure akinesia, Alzheimers disease, Picks disease, prion disease, corticobasal degeneration, diffuse Lewy body disease, Huntingtons disease.
