The present invention discloses quinoline compounds, a preparation methodthereof, and a use thereof as a uratetransporter inhibitor drug. The compounds and salts, hydrates or solvatesthereof provided in the present invention, as a selectiveuric acid reabsorption inhibitor, have the effect of reducing uric acid inanimal and human body and can treat hyperuricemia andgout by promoting secretion of uric acid from the body and reducing serum uricacid.