Leon F. GARCIA-MARTINEZ,Andrew L. Feldhaus,Katie Anderson,Benjamin H. Dutzar,John A. Latham
申请号：
US14212104
公开号：
US20140271464A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof (especially chimeric and humanized) having binding specificity for HGF and their use in therapy and diagnosis. These antibodies inhibit or block HGF-associated activities including HGF's effects on cell proliferation, invasion, angiogenesis, metastasis and fibrosis. Particularly the antibodies may be used as a monotherapy or in combination therapies in treating cancer, other proliferative disorders and other conditions wherein inhibition of HGF and/or the HGF/HGF-R (c-met) interaction is desired.
