PROBLEM TO BE SOLVED: To provide an inhibitor in which the expression of transglutaminase 1 to be considered as involved in keratotic disorder of skin and the differentiation of keratinocyte are conveniently, inexpensively and effectively inhibited by using RNA interference as a gene expression inhibitory means.SOLUTION: Disclosed are a vasoactive intestinal contractor (VIC) gene to be considered as involved in the disorder, an expression inhibitor for the gene which targets the partial sequence of ET-2/VIC mRNA and contains siRNA or shRNA (short hairpin RNA) as an active ingredient, and a drug composition thereof to be used for the prevention/treatment of keratotic disorder, the prevention/treatment of cancer and the like.COPYRIGHT: (C)2008,JPO&INPIT【課題】RNA干渉を遺伝子発現抑制手段として用い、簡便、安価、かつ有効に、皮膚角化異常に関与すると考えられている、トランスグルタミナーゼ1の発現と、ケラチノサイトの分化を抑制する薬剤を提供する。【解決手段】上記異常に関与すると考えられるVIC(Vasoactive Intestinal Contractor)遺伝子、ET-2/VIC mRNAの部分配列を標的とする、siRNA又はshRNA(ショートヘアピンRNA)を有効成分として含有する、該遺伝子発現抑制剤、角化異常障害の予防・治療、癌の予防・治療等に用いるその医薬組成物。【選択図】なし
