COMPOSITION, METHODS FOR PREPARING A VACCINE AGAINST ADJUSTED INFLUENZA, AND FOR MANUFACTURING VACCINE, VACCINE KIT, VACCINE, AND USES OF AN ANTIGEN INFLUENZA VIRUS OR PREPARATION OF THE SAME WATER AND OIL EMULSION AN ANTIGEN
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant composition comprising an oil-in-water emulsion, wherein said oil-in-water emulsion comprises a metabolisable oil at a level of below 11 mg and an emulsifying agent at a level of below 5 mg and optionally a tocol or a sterol at a level of below 12 mg. Suitably the amount of influenza antigen per strain per dose is 15 pg HA or a low amount such as less than 15 pg HA.
