Jennifer H. Elisseeff,Qiongyu Guo,Shoumyo Majumdar,Anirudha Singh
申请号：
US15306146
公开号：
US20170182213A1
申请日:
2015.09.10
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present inventors employed cyclodextrins for use as a proteoglycan substitute to engineer a biomimetic collagen-based matrix composition. The resulting incorporation of cyclodextrin in the inventive collagen compositions increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen-based composition was formed. This cyclodextrin-collagen composition holds a great potential to be used as a therapeutic eye patch for corneal repair. Additionally, the composition can support development of multi-layered structures, with different layers promoting different biological properties. Methods for making these inventive compositions and their use are also provided.
