#$%^&*AU2018201363A120180315.pdf#####Abstract The present invention relates to pyrazine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutical acceptable compositions comprising the compounds of this invention； me thods of treating of various diseases, disc rders, and conditions using the compounds of this invention； processes for preparing the compounds of this invention； intermediates for the preparation of the compounds of this invention； and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena； the study of intracellular signal transduction pathways mediated by such kinases； and the com parative evaluation of n ew kin ase inhibitors. The compo un ds of this invention have formula (1):wherein the variables are as defined herein NH2 N r N R2
