Producing a hemocompatible material having a synthetic, resistant and waterproof substrate, and an animal tissue, chemically fixed to avoid immunological reactions, comprises drying the tissue, adhering the tissue on the substrate using a dispersion of the constituent material of the substrate in a solvent of material, and eliminating the solvent, where the dehydration is obtained only by chemical immersion of the animal biological tissue in a bath constituted of polyethylene glycol solution of at least 80 wt.%. Producing a hemocompatible material comprising a synthetic, resistant and waterproof substrate, and an animal tissue, chemically fixed to avoid immunological reactions, comprises drying the animal tissue, adhering the dried animal tissue on the synthetic substrate using a dispersion of the constituent material of the synthetic substrate in a solvent of material so that the constituent material impregnates the animal tissue, and eliminating the solvent, where the dehydration is obtained only by chemical immersion of the animal biological tissue in a bath constituted of polyethylene glycol solution of at least 80 wt.%.本発明は、合成基材と動物の生体組織とを含む血液適合性材料を製造する方法に関し、この方法によれば、動物の生体組織が脱水され、合成基材を形成する材料の分散物を用いることによって、合成基材に付着する。本発明によれば、動物の生体組織は、ポリエチレングリコールを少なくとも80重量%含む溶媒からなる溶液に動物の生体組織を浸すことによってのみ、化学的に脱水される。【選択図】 なし