A device and method are provided for therapy and treatment of biological tissue such as muscle, tendon, and ligament tissue, by use of a device and method in which therapeutic vibrational frequency resonance patterns are transmitted to tissues of a patient. The resonance frequencies originate from many resonance domains, including vitamins, minerals, herbs, amino acids, and fatty acids. Each domain includes therapeutic frequency resonance patterns. These resonance patterns may be passively excited and transmitted to a patient to enhance tissue function, to decrease the normal rehabilitation time of damaged tissue, and provide therapeutic benefits for muscle tissue dysfunction. Therapeutic frequency resonance patterns may also be actively excited by a delivery mechanism that uses electromagnetic or mechanical waves to interact with the device. The actively excited device transmits the therapeutic frequency resonance patterns to the patients for similar enhancements and therapeutic benefits.