FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL);INSTITUT CATALÀ D'ONCOLOGIA (ICO)
发明人:
Ramon Alemany Bonastre,Luis Alfonso Rojas Expósito
申请号：
US15307408
公开号：
US20170051022A1
申请日:
2015.04.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to a recombinant adenovirus comprising an albumin-binding moiety on the outer surface of the adenoviral hexon protein, pharmaceutical compositions containing it and its medical use. Particularly, the invention relates to an oncolytic adenovirus comprising a sequence encoding an albumin-binding moiety inserted in the hypervariable region 1 (HVR1) of the hexon protein coding sequence and its use in the prevention and/or treatment of cancer.
