PROBLEM TO BE SOLVED: To provide a determination method of pancreatic cancer treatment sensibility.SOLUTION: A determination method of pancreatic cancer treatment sensibility comprises (1) measuring at least one kind of miRNA expression level selected from the following miRNAs, in each sample derived from cancerous region or stroma collected from the tumor tissue of human pancreatic cancer and (2) determining that the pancreatic cancer treatment sensibility of the tumor tissue is low if the measurement value of the sample derived from the stroma obtained in the step (1) is larger as compared with the measurement value of the sample derived from the cancerous region, in all kinds of miRNAs measured in the step (1). hsa-miR-4689 hsa-miR-4664-5p hsa-miR-4731-5p hsa-miR-187-5p hsa-miR-4270 hsa-miR-4697-5p hsa-miR-4723-5p hsa-miR-6087 hsa-miR-145-5p and hsa-miR-125b-5p.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】膵癌治療感受性の判定方法の提供。【解決手段】膵癌治療感受性の判定方法であって、(1)ヒト膵癌の腫瘍組織から採取した癌部及び間質由来の検体それぞれにおける、以下のmiRNAから選択される少なくとも一種のmiRNAの発現量を測定する工程;及び(2)前記工程(1)で測定したmiRNAの全種において、前記工程(1)で得られた、間質由来検体の測定値が、癌部由来検体の測定値と比較してより大きければ、当該腫瘍組織の膵癌治療感受性が低いと判定する工程を含む方法。hsa-miR-4689;hsa-miR-4664-5p;hsa-miR-4731-5p;hsa-miR-187-5p;hsa-miR-4270;hsa-miR-4697-5p;hsa-miR-4723-5p;hsa-miR-6087;hsa-miR-145-5p;及びhsa-miR-125b-5p。【選択図】なし
