A germ/barrier travel kit sized, shaped and configured to carry articles necessary for germ prevention and sterilization. In one embodiment, the germ/barrier travel kit consists of a bag/container including but not limited to: toilet seat cover, face mask, gloves, head rest cover and hygiene/disinfecting wipes. However, the germ/barrier travel kit may also be configured to carry additional wipes or barriers. The germ/barrier travel kit is configured to permit ready and easy access to articles needed by travelers to defend against germs and preventing disease transmission.