Disclosed is a sealing device for repair of cardiac and vascular defects or tissue opening such as a patent foramen ovale (PFO) or shunt in the heart, the vascular system, etc. and particularly provides an occluder device and trans-catheter occluder delivery system. The sealing device has improved conformity to heart anatomy and be easily deployed, repositioned, and retrieved at the opening site. The sealing device comprises an expandable frame consisting of wires extending from a proximal end to a distal end of the frame. The wires form proximal, intermediate and distal eyelets. A sealing member at least partially encapsulates the expandable wire frame. The sealing member may for example be thin material of ePTFE adhered to the frame by the FEP adhesive.
