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DEPOT COMPOSITIONS OF LOCAL ANESTHETIC AND WAYS OF THEIR OBTAINING
专利权人:
ПЕЙНРЕФОРМ ЛТД. (IL)
发明人:
АМСЕЛЕМ Шимон (IL),НАВЕХ Михаэль (IL)
申请号:
RU2014144500
公开号:
RU2014144500A
申请日:
2013.05.09
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A proliposomal non-aqueous pharmaceutical composition comprising: a local anesthetic or a pharmaceutically acceptable salt thereof; a natural non-synthetic phospholipid; a non-aqueous pharmaceutically acceptable carrier; and a solvent as a viscosity regulator, wherein said composition is in the form of a clear solution containing no particles larger than 100 nm, stable at ordinary temperature and essentially free of water. 2. A composition according to claim 1, wherein said composition is stable for at least six months at room temperature. The composition according to claim 1, wherein said co-solvent is a non-aromatic co-solvent. The composition of claim 3, wherein said non-aromatic cosolvent is ethanol. 5. The composition according to claim 1, wherein its viscosity is in the range of 1000-2000 cPoise. 6. A composition according to claim 1, not containing particles larger than 50 nm. The composition of claim 1, wherein said local anesthetic is ropivacaine. The composition according to claim 1, wherein said composition forms liposomes in vivo after contact with body fluids. The composition of claim 4, wherein ethanol is present in an amount of from about 1% to about 15% by weight. The composition of claim 1, wherein said local anesthetic is present in an amount equivalent to from about 0.2% to about 12% by weight. The composition of claim 10, wherein said local anesthetic is present in an amount equivalent to from about 3% to about 6% by weight. A composition according to claim 1, wherein said natural non-synthetic phospholipid is present in an amount of from about 40% to about 60% by weight. The composition of claim 1, wherein said natural non-synthetic phospholipid is present1. Пролипосомная неводная фармацевтическая композиция, содержащая:местный анестетик или его фармацевтически приемлемую соль;природный несинтетический фосфолипид;неводный фармацевтически приемлемый носитель; исорастворитель в качестве регулятора вязкости,где указанная композиция представлена
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