Methods for modifying endoplasmic reticulum processing of protein

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专利权人:

Memorial Sloan Kettering Cancer Center

发明人:

Goldberg, Jonathan,Goldberg, Elena,Ma, Wenfu

申请号：

AU2018269937

公开号：

AU2018269937A1

申请日:

2018.05.18

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present disclosure provides compositions and methods for modifying endoplasmic reticulum trafficking of proteins. Also disclosed herein are methods for treating cancer and/or enhancing cancer or viral immunotherapy in a subject by increasing the extracellular secretion levels of GRP94 in the subject. Such methods comprise administering to the subject an effective amount of 4-PBA and/or a 4-PBA analog selected from among methoxy- PBA, 3-PPA, 5-PVA, hydroxy-PPA, hydroxy-PBA, and tolyl-BA.

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中国工程科技知识中心

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http://www.ckcest.cn/home/