LIPOSOMI S LIPIDIMA KOJI IMAJU VRIJEDNOST pKa POVOLJNU ZA UNOS RNA

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专利权人:

GLAXOSMITHKLINE BIOLOGICALS SA

发明人:

GEALL, ANDREW

申请号：

HRP20151349

公开号：

HRP20151349T1

申请日:

2015.12.08

申请国别(地区):

HR

年份:

2016

代理人:

摘要：

RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.

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