SOLL, MARK, DAVID,LE HIR DE FALLOIS, LOIC, PATRICK,HUBER, SCOT, KEVIN,LEE, HYOUNG, IK,WILKINSON, DOUGLAS, EDWARD,JACOBS, ROBERT, TOMS,BECK, BRENT, CHRISTOPHER
申请号：
NZ59298009
公开号：
NZ592980A
申请日:
2009.11.13
申请国别(地区):
NZ
年份:
2013
代理人:
摘要：
592980 Disclosed herein are aryloazol-2-yl-cyanoethylamino derivatives of formula (I), wherein the variables are defined in the specification, processes for their preparation, and a method for treating parasitic infection or infestation in a non-human animal comprising administering said derivatives. Specifically wherein the parasite is Anaplocephala, Ancylostoma, Anecator, Ascaris, Brugia, Bunostomum, Capillaria, Chabertia, Cooperia, Cyathostomum, Cylicocyclus, Cylicodontophorus, Cylicostephanus, Craterostomum, Dictyocaulus, Dipetalonema, Dipylidium, Dirofilaria, Dracunculus, Echinococcus, Enterobius, Fasciola, Filaroides, Habronema, Haemonchus, Metastrongylus, Moniezia, Necator, Nematodirus, Nippostrongylus, Oesophagostumum, Onchocerca, Ostertagia, Oxyuris, Paracaris, Schistosoma, Strongylus, Taenia, Toxocara, Strongyloides, Toxascaris, Trichinella, Trichuris, Trichostrongylus, Triodontophorous, Uncinaria or Wuchereria. Specific embodiments of the compound include: (+)-N-[2-(6-bromo-2H-pyrazolo[4,3-b]pyridin-2-yl)-1-cyano-1-methylethyl]-4- trifluoromethoxybenzamide, N-[1-cyano-2-(6,7-dichloro-2H-indazol-2-yl)-1-methylethyl] trifluoromethoxybenzamide, methyl 6-chloro-2-[2-cyano-2-({ [4-(trifluoromethoxy)phenyl]carbonyl} -amino)propyl]-2H-benzotriazole-4-carboxylate, and N-[2-(5-chloro-4,7-dimethyl-2H-benzotriazol-2-yl)-1-cyano-1-methylethyl]-4-trifluoromethylthiobenzamide.
