GRIFFIOEN, Gerard,CECERE, Giuseppe,NETTEKOVEN, Matthias,PRINCEN, Katrien,RATNI, Hasane,ROGERS-EVANS, Mark,VIFIAN, Walter
申请号：
ES12756402
公开号：
ES2573299T3
申请日:
2012.08.17
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula IA or a pharmaceutically active salt thereof, a stereoisomeric form, which includes an individual diastereoisomer or enantiomer of the compound of formula (IA) as well as a racemic or non-racemic mixture thereof； ** Formula ** where G1 it is lower alkyl； lower alkyl substituted by one or more halogens； tetrahydropyran-4-yl； phenethyl； phenethyl substituted by one or more halogens； phenoxymethyl； phenoxymethyl substituted by one or more halogens； benzyloxyethyl； benzyloxy-ethyl substituted by one or more halogens； or is -NR2R3； R2 is hydrogen or lower alkyl； R3 is lower alkyl, tetrahydropyran-4-yl-CH2-cycloalkyl or cycloalkyl optionally substituted by lower alkyl substituted by one or more halogens； or R2 and R3 together with the N atom to which a heterocycloalkyl group with 4 or 5 carbon atoms is attached, which is optionally substituted by one or more substituents selected from halogen or lower alkyl substituted by one or more halogens； X is -CH2- or - (CH2) 2-； Ar is phenyl or pyridinyl； R4 is halogen； lower alkyl； lower alkyl substituted by one or more halogens； or lower alkoxy； n is 1 or 2； where the term "lower alkyl" denotes a saturated straight or branched chain group containing from 1 to 7 carbon atoms； the term "lower alkyl substituted by halogen" denotes an alkyl group as defined above, where at least one hydrogen atom is substituted by halogen； the term "lower alkoxy" denotes a group where the alkyl residue is as defined above and is linked by means of an oxygen atom； or wherein said compound is: 1- (3-Cyclohexyl- [1,2,4] thiadiazol-5-yl) -4- [2- (4-methoxy-phenyl) -ethyl] -piperazine； 1- (3-Cyclohexyl- [1,2,4] thiadiazol-5-yl) -4- [2- (3-methoxy-phenyl) -ethyl] -piperazine； 1- (3-Cyclopropyl- [1,2,4] thiadiazol-5-yl) -4- [2- (4-methoxy-phenyl) -ethyl] -piperazine； 1- (3-Cyclopropyl- [1,2,4] thiadiazol-5-yl) -4- [2- (3-methoxy-phenyl) -ethyl] -piperazine with the proviso that said compound is not: - (4- (3-Fluorobenzyl) piperazin-1-y
