LOW-MOLECULAR-WEIGHT GLYCOSAMINOGLYCAN DERIVATIVE CONTAINING TERMINAL 2, 5-ANHYDRATED TALOSE OR DERIVATIVE THEREOF

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专利权人:

发明人:

Jinhua ZHAO,Mingyi WU,Na GAO,Zi LI,Sensen LAI,Longyan ZHAO

申请号：

US14779934

公开号：

US20160060364A1

申请日:

2013.12.20

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2,5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.

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