LEE, DER-YANG,SHEN, ROBERT,CHEN, JEN-CHI,CHEN, VINCENT
申请号：
NZ58130408
公开号：
NZ581304A
申请日:
2008.06.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a solid or semi-solid pharmaceutical dosage form comprising: a) a first portion containing a first active ingredient comprised of an NSAID and/or a pharmaceutically acceptable salt thereof, wherein the first active ingredient is released from the dosage form in a substantially immediate manner upon contact of the dosage form with a dissolution medium and b) a second portion containing i. particle cores comprised of a second active ingredient, which is different from the first active ingredient ii. a semi-permeable coating layer substantially covering said particle cores to form coated particles and iii. a protective coating layer substantially covering said coated particles, wherein the second active ingredient is released from the second portion in a modified release manner upon contact of the dosage form with the dissolution medium, and wherein the duration of the therapeutic effect of the second active ingredient as released from the second portion of the dosage form is substantially the same as the duration of the therapeutic effect of the first active ingredient. Example of a NSAID is Ibuprofen and an example of a second active ingredient is phenylephrine.
