A medical appliance designed to adhere to the skin proximate a stoma or other open wound with an adhesive layer including two or more different composition pressure sensitive adhesives. One adhesive is skin friendly, having excellent tack properties, and painless removability. The other adhesive is flexible and comfortable to wear, has high moisture tolerance and the ability to swell to create a seal around the stoma. It has minimal cold flow and will not discolor significantly when sterilized.
