DIWAN, ANIL, R,ONTON, ANN, LOUISE,TATAKE, JAYANT G
申请号：
NZ58121007
公开号：
NZ581210A
申请日:
2007.07.19
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the use of an anticancer drug in the preparation of a medicament for the treatment of cancer, wherein the anticancer drug is encapsulated within a comb polymer, said comb polymer consisting essentially of the structure shown herein, which comprises a backbone formed of alternating branch-point moieties B and hydrophilic, water-soluble polymer blocks A and having hydrophobic side chains C and targeting moieties Z attached to the branch-point moieties, wherein: each hydrophobic side chain C is independently selected from the group consisting of C6-C30 linear or branched hydrocarbons optionally substituted with one or more hydrophilic substituents C6-C30 cyclic or polycyclic hydrocarbons optionally substituted with one or more hydrophilic substituents and hydrophobic amino acids, peptides and polymers each targeting moiety Z is independently a ligand having specific binding affinity for the surface of said cancer cells s is a bond or a spacer moiety the value of n ranges from 1 to about 100 the average value of p ranges from greater than one to four and the average value of r ranges from 0 to 8.
