Albert Jean Robichaud,Francesco G. Salituro,Boyd L. Harrison,Gabriel Martinez Botella,Jeffrey Jonas
申请号：
US15565645
公开号：
US20180311258A1
申请日:
2016.04.08
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are deuterium-enriched neuroactive steroids of the Formula (II) or a pharmaceutically acceptable salt thereof wherein R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R11a, R11b, R12a, R12b, R16a, R16b, R17, R19, Ra, and Rb and subvariables thereof are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment.
