OREGON HEALTH & SCIENCE UNIVERSITY;SANOFI PASTEUR, INC.
发明人:
ROSS, TED MILBURN,ALEFANTIS, TIM,CARTER, DONALD MARTIN, JR.,DARBY, CHRISTOPHER AUSTIN,KLEANTHOUS, HAROLD
申请号：
CA2970158
公开号：
CA2970158A1
申请日:
2015.12.18
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention provides co-administration (for example, immunogenic cocktail compositions and/or prime-boost regimens) of computationally optimized H1N1 influenza hemagglutinin (HA) polypeptides. Co-administration of the optimized H1N1 influenza hemagglutinin (HA) polypeptides facilitates synergistic neutralization of viral infection and provides for improved protective immunity (e.g., a broad reactive immune response) to diverse and multiple H1N1 influenza virus strains, including both seasonal and pandemic strains.
