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ЛЕКАРСТВЕННЫЕ СРЕДСТВА, СОДЕРЖАЩИЕ АМИНОКИСЛОТНЫЕ ПОСЛЕДОВАТЕЛЬНОСТИ ИНСУЛИНА
专利权人:
ФЭЙЗБИО ФАРМАСЬЮТИКАЛЗ; ИНК. (US)
发明人:
ДЖОВЕТТ Джеймс (US),ВУДС Кристофер (US)
申请号:
RU2014126244
公开号:
RU2014126244A
申请日:
2012.11.28
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A pharmaceutical composition for long-term glycemic control, comprising an effective amount of a protein comprising the amino acid sequence and amino acid sequence of insulin, providing a sustained release from the injection site and pharmaceutical excipients for achieving sustained vysvobozhdeniya.2. A pharmaceutical composition according to claim 1, characterized in that the amino acid sequence of insulin comprises the amino acid sequence A-chain and B-chain, wherein the A-chain and B-chain have an amino acid sequence of SEQ ID NO:. 13 optionally having from 1 to 8 amino acid insertions, deletions or substitutions sovokupno.3. A pharmaceutical composition according to claim. 2, characterized in that the amino acid sequence which provides the slow absorption from the injection site, covalently linked to the A-chain insulina.4. A pharmaceutical composition according to claim. 2 or 3, characterized in that the A-chain and B-chain are linked by one or more disulfide svyazyami.5. A pharmaceutical composition according to claim. 2 or 3, characterized in that the A-chain and B-chain are bonded via peptide or chemical linker.6. A pharmaceutical composition according to claim. 1, characterized in that the amino acid sequence, which provides a sustained release, has a substantially repeating pattern prolina.7 residues. A pharmaceutical composition according to claim. 6, characterized in that the amino acid sequence that provides sustained release is the amino acid sequence elastinopodobnogo peptide (ELP) .8. A pharmaceutical composition according to claim. 7, wherein the ELP comprises repeats VPGXG (SE1. Фармацевтическая композиция для обеспечения длительного гликемического контроля, содержащая эффективное количество белка, содержащего аминокислотную последовательность инсулина и аминокислотную последовательность, обеспечивающую замедленное высвобождение из места инъекции и фармацевтические наполнители для достижения замедленного высвобождения.2. Фармацевтическая компози
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