Process for manufacturing a bone prosthesis for implanting in a bone of a patient, comprising - performing, from a footprint skin or mucosa of the patient, a surgical guide provided with at least an artificial prosthesis and at least one first hole through each, one above artificial prosthesis in a predetermined orientation, - positioning the surgical guide on a model obtained from the footprint, - drilling through the model a second hole with the help of a past drill through each first hole, wherein the second hole the predetermined orientation of its corresponding first hole, - placing, in each second drill hole, an analog implant having dimensions that correspond to an actual implant to be placed in the bone patient, this placement being effected by a last portaanálogo through the corresponding first hole, - fixing the analys OGO implant in the second hole, as it has been placed, and - after removal of each portaanálogo and the surgical guide, make a final bone prosthesis adapted to provided the or analogs implant model and intended to be fixed on one or a real implants after implantation in the patient's bone with the help of the surgical guide, in a manner similar to that used for positioning the implant analogues in the model, characterized by further comprising - for drilling a second hole, passing the drilling and / or an extension element of this through the corresponding first hole without contact with this and - guide the drill along said predetermined direction by means of introducing hole located outside said first hole.Procedimiento de fabricación de una prótesis ósea para implantar en un hueso de un paciente, que comprende - realizar, a partir de una huella de piel o de mucosas del paciente, una guía quirúrgica dotada de al menos una prótesis artificial y de al menos un primer agujero que atraviesa, cada uno, una prótesis artificial antedicha siguiendo una orientación predeterminada, - colocar la guía quirúrgica sobre un modelo obtenido a partir de di
